Natural is always best. Natural, whole foods are healthier than processed ones. Natural hormones are better and safer than synthetic ones from all that I’ve read and from what two of my doctors have told me. I doubt my gynecologist would tell me that, though. I think all he prescribes are the synthetic hormones. My regular doctor prescribes natural, compounded from a pharmacy progesterone. If your hormones are giving you a lot of trouble, if you gain weight and can’t seem to lose it, or you’re having any of the many symptoms that estrogen dominance can cause, you might want to check into natural progesterone. Natural is the best way to go.